Killer T-Cell Attacking Cancer
A major advance in cancer research is harnessing the capacity of the immune system to track down and destroy tumor cells. Here, Cytotoxic T lymphocytes (green) kill virally infected and tumor cells (red) by secreting cytolytic proteins. The centrosome (red dots) determines where secretion occurs by contacting the plasma membrane at the point where the T cell recognizes the tumor cell.
Movie: The attacking CTL is visualized with an intensity spectrum that lights up actin. In both videos the CTLs express Cherry and GFP fusion proteins, which mark the centrosome and actin, respectively. Target cells express a blue plasma membrane fusion protein; nuclei are labeled in blue. Movie editing and narration by Cambridge University.
This is awesome.